Mass spectrometry-based assay that rapidly profiles the entire proteome to identify and validate DUB targets and determine the mechanism of action for novel DUB targeting compounds

PROTEOMEprofiler™ is a multiplexed mass spectrometry assay that rapidly profiles the entire cellular proteome and reports changes in response to stimuli. The assay allows the comparison of non-diseased and diseased cellular states to identify and validate novel DUB targets and provides an unbiased analysis of cellular responses to DUB targeting compounds to reveal their mechanism of action.

PROTEOMEprofiler can also determine the relative efficacy (EC50), selectivity, dose, and concentration dependency of compounds such as DUB inhibitors, DUB-targeting PROTACs and DUBTACs.